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Year : 2007  |  Volume : 4  |  Issue : 2  |  Page : 50-52

Autoimmune thyroid disease and pregnancy outcome - a prospective observational study

Department of Obstetric and Gynaecology, SSKM Hospital and IPGME&R, Kolkata, India

Correspondence Address:
A Mukhopadhyay
Department of Obstetric and Gynaecology, SSKM Hospital and IPGME&R, Kolkata
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Source of Support: None, Conflict of Interest: None

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This study was conducted to find out the frequency of clinical and subclinical hypothyroidism in pregnant women in our population, the prevalence of anti-TPO positivity in those with clinical and subclinical hypothyroidism and to compare obstetric and perinatal outcomes in these subgroups. Six hundred and fifty consecutive pregnant women were screened for hypothyroidism. Anti TPO antibody was tested in the hypothyroid women. They were followed up for pregnancy outcome separately. Incidence of hypothyroidism in pregnancy was 3.69%. Incidence of clinical and subclinical hypothyroidism was 0.61% and 3.07% respectively. Five out of twenty four (20.8%) were TPO-antibody positive and rest nineteen women (79.2%) were TPO-antibody negative. Maternal complications like hypertension, pre-eclampsia, and GDM as well as fetal complications like abortion, IUGR were more common in antibody positive women. Pregnancy with hypothyroidism is associated with increased maternal antenatal and fetal complications, more so in those with positive TPOantibody. Hence besides screening with TSH, TPO antibody should be done in all cases if possible.

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