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Year : 2008  |  Volume : 5  |  Issue : 3  |  Page : 83-89

Cytotoxic effects of low dose 13I I therapy - Assessment of chromosomal aberration and micronucleus as biomarkers

1 Department of Biotechnology, Karpagam Arts and Science College, Coimbatore, Tamil Nadu, India
2 Department of Nuclear Medicine, Amrita Institute of Medical sciences, Cochin, Kerala, India
3 Unit of Human Genetics, Department of Zoology, Bharathiar University, Coimbatore, Tamil Nadu, India

Correspondence Address:
S Sudha
Department of Biotechnology, Karpagam Arts and Science College, Coimbatore, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

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There are articles describing the various cellular effects after a high dose I 131 therapy, which serves as the first line of management in postoperative cases of differentiated thyroid carcinoma. We aimed to study the cytotoxic effects of a low dose 1S1 I therapy used as treatment modality for hyperthyroid patients. Peripheral blood lymphocytes from a group of 20 patients, who received 1S1 I sodium iodide solution orally, were studied for the presence of Chromosomal Aberrations (CA) and Micro Nucleus (MN) using micronucleus assay. The study was conducted using blood samples of such patients drawn prior to the treatment, on 7 th day and 30 th day after the treatment. The results indicate a positive relationship between dose, CA and MN frequency. A statistically significant increase in CA and MN frequency in 7 th day post therapy and a decrease in mean levels of CA and MN at 30 th day post therapy were observed when compared to pretherapy. This study showed that the cytogenetic damage induced by a low dose beta emitter like 1S1 I is minimal and reversible.

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