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Year : 2010  |  Volume : 7  |  Issue : 3  |  Page : 84-90

Fixed dose radioactive iodine therapy in hyperthyroidism- outcome and factors affecting it in a region in South India

Department of Nuclear Medicine, Amala Institute of Medical Sciences, Amalanagar, Thrissur-555, Kerala, India

Correspondence Address:
A S Shinto
Department of Nuclear Medicine, Amala Institute of Medical Sciences, Amalanagar, Thrissur-555, Kerala
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Source of Support: None, Conflict of Interest: None

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Objective: Radioactive iodine-131 (RAI) has been established in the treatment of patients with various etiologies of hyperthyroidism. However the short term and long term clinical outcome of patients receiving RAI is different in various studies. The aim of this study was to assess clinical outcome one year after RAI therapy and identify factors associated with a good response. Methods: In this experimental study among patients with Graves'disease, multinodular goiter and toxic adenomas referred to the Nuclear Medicine Department and had indication for RAI therapy 164 subjects were selected randomly. Radioiodine dose was calculated on the basis of the size of the thyroid gland by physical examination. Patients with normal thyroid gland were given less than 10 mCi and if it was large or in the presence of thyroid nodularity a dose of greater than 10 mCi (approximately 15 mCi) was administered. Patients were monitored closely clinically and with blood investigations after treat­ment for one year. Results: Among 158 patients who completed follow up 98.8% recovered and 1.2 % remained thyrotoxic .Among patients who recovered 74.2% became hypothyroid and 22.6%> euthyroid. The incidence of hypothyroidism was 23 % in first trimester, 43.7% in second trimester, 4.4% in third trimester and 3.1% in forth trimester. Conclusion: In our study a good result was seen in more patients than other studies and it might relate to higher absorption of radioactive iodine in our region. According to our result incidence of hypothyroidism was the most in second trimester, so patients should be carefully followed in this period.

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