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Year : 2011  |  Volume : 8  |  Issue : 2  |  Page : 3-12

Evaluation of the clinicopathological profile of solitary thyroid nodules: Our experience

1 Department of Surgery, Maulana Azad Medical College and associated hospitals, New Delhi, India
2 Department of Biochemistry, Maulana Azad Medical College and associated hospitals, New Delhi, India
3 Department of Radioiodine Uptake and Imaging, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India

Correspondence Address:
B Goswami
Department of Biochemistry, Maulana Azad Medical College and associated hospitals, New Delhi
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Source of Support: None, Conflict of Interest: None

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Background:  Thyroid nodules are commonly encountered in clinical practice, with up to 8% of the adult population having palpable nodules. The concern with thyroid nodules is the differentiation between benign and malignant nodules. The aim of this study was to evaluate the demographic, ultrasonographic, fine needle aspiration cytology, histology and scintigraphic findings in differentiating benign from malignant thyroid lesions in patients presenting with thyroid nodules. Methods:  A total of 1264 patients with thyroid disorders were screened in the OPD for fulfillment of the inclusion criteria. All patients presenting with a clinically palpable nodule were included in the study. A total of 218 patients were finally enrolled after informed consent. The various investigations that were carried out include Thyroid Function Tests (TFT), Fine Needle Aspiration Cytology (FNAC), ultrasonography (USG) and radionuclide scanning. Results:  One hundred and thirty eight out of the 218 cases were operated upon and 78 patients were managed conservatively. A total of 94 patients presented with non neoplastic thyroid nodules. Approximately 89% were females while 11% were males. Approximately 80% of the patients with benign nodules were euthyroid, while all the patients with malignancies had no thyroid abnormality. FNAC was not of much utility in differentiating between benign and malignant thyroid neoplasms. Conclusions:  A battery of investigative procedures, instead of a solitary test can differentiate between benign and malignant thyroid nodules.

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