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Year : 2012  |  Volume : 9  |  Issue : 2  |  Page : 53-55

Kocher-Debre-Semelaigne syndrome

1 Department of Medicine, Lala Lajpat Rai Memorial Medical College, Meerut, Uttar Pradesh, India
2 Department of Endocrinology, Lala Lajpat Rai Memorial Medical College, Meerut, Uttar Pradesh, India

Correspondence Address:
Satyam Rajvanshi
F16, PG Hostel, Lala Lajpat Rai Memorial Medical College Campus, Garh Road, Meerut, Uttar Pradesh 250 004
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-0354.96047

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Thyroid hormone deficiency is an unusual cause of acquired myopathy, although complaints of muscular weakness can be present in up to 40% of patients. Among the patients with myopathy, <10% of the patients develop pseudomuscular hypertrophy known as Kocher-Debre-Semelaigne syndrome (KDS) in children and Hoffmann syndrome in adults. We report a case of autoimmune hypothyroidism where weakness and growth failure were predominant complaints, and hypertrophied calf muscles were easily noticeable. Although rare, KDS remains an easy to diagnose and treatable cause of reversible myopathy and therefore, must be considered in differential diagnosis of hereditary myopathies.

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