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Year : 2012  |  Volume : 9  |  Issue : 3  |  Page : 84-87

Implication of altered thyroid state on liver function

Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria

Correspondence Address:
Roland E Akhigbe
Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-0354.99649

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Objective: The thyroid gland is essential for metabolism and normal function of body cells, including the liver cells. It helps in the development and maturation of the hepatocytes and other body cells and tissues. This study investigated the effect of altered thyroid state on liver function. Materials and Methods: Rats were randomized into three groups: control, hypothyroid, and hyperthyroid rats. Results: Thyroid dysfunction led to lysis of the hepatocytes. Hypothyroidism caused significant (P < 0.05) reduction of body weight gain, serum total protein, albumin, direct bilirubin, transaminases, and gamma glutamyl transferase. Hyperthyroidism led to significant (P < 0.05) body weight loss. Hypothyroidism and hyperthyroidism were associated with significant (P < 0.05) increase in liver weight and diameter. Conclusion: This study reveals that although hyperthyroid state is not associated with altered liver function, hypothyroidism caused hepatic dysfunction. We therefore suggest that liver function indices should be monitored in altered thyroid states, especially in hypothyroidism.

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