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Year : 2015  |  Volume : 12  |  Issue : 2  |  Page : 67-70

Thyroid status of the pregnant women of Manipur: A comparison of American Thyroid Association guidelines and normal laboratory reference range

1 Department of Medicine, Regional Institute of Medical Sciences, Imphal, Manipur, India
2 Department of Obstetrics and Gynecology, Regional Institute of Medical Sciences, Imphal, Manipur, India

Correspondence Address:
Lallan Prasad
Department of Medicine, Regional Institute of Medical Sciences, imphal, manipur. Pin Number 795004
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-0354.153344

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Gestation is the period when the thyroid function parameters undergo several changes. As the range of thyroid hormone levels differ in the gestational period due to the various physiological changes, the hormonal range, which is used for the normal population cannot be used for pregnant women. Our study was done to find the thyroid status of pregnant women by comparing the trimester specific range as published by American Thyroid Association (ATA) guidelines with the normal population/laboratory reference range. A total of 377 patients with a distribution of 110,149 and 118 among the trimesters were studied. One patient each in first and second trimester had overt hypothyroidism when trimester specific reference range as published by ATA was followed. The prevalence of subclinical hypothyroidism as per ATA guidelines were 34.4, 31.5 and 30.5%, in the respective trimesters. The prevalence of subclinical hypothyroidism on taking into account the normal laboratory reference range of 3.6, 2.6 and 6.8% in the respective trimesters. Overt hypothyroidism was seen, one each in the first and second trimester and 29.3% were misdiagnosed as normal patients in this study. It is inferred that large number of patients will be misdiagnosed as having normal thyroid function during pregnancy if the trimester specific reference range is not followed. Thus we conclude that the pregnancy reference range should be used to interpret the thyroid hormones in pregnancy to avoid the misdiagnosis, as thyroid hormones are necessary for the normal fetal brain development.

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