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Year : 2015  |  Volume : 12  |  Issue : 2  |  Page : 71-73

Life threatening ANCA associated vasculitis on Carbimazole exposure

1 Department of Endocrinology, Army Hospital, Delhi Cantt, India
2 Department of Rheumatology, Army Hospital, Delhi Cantt, India

Correspondence Address:
Vimal Upreti
Department of Endocrinology, Army Hospital, Delhi Cantt 110 010
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-0354.153343

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ANCA-associated vasculitis is a rare side effect of commonly used thionamide group of anti-thyroid drugs. It is most commonly associated with use of propylthiouracil and p-ANCA positivity. However, rarely it has been reported with carbimazole exposure and c-ANCA positivity. Here we report a case of life-threatening episode of c-ANCA-associated vasculitis in a female patient of Graves' disease on exposure to carbimazole, who was managed successfully by discontinuation of carbimazole and immunosuppressive therapy. A high index of suspicion is required for diagnosing such cases, who if not diagnosed correctly, may have adverse outcome.

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