Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Home Print this page Email this page
Users Online: 115

Year : 2019  |  Volume : 16  |  Issue : 1  |  Page : 12-19

Guwahati thyroid epidemiology study: High prevalence of primary hypothyroidism among the adult population of Guwahati city

1 Department of Endocrinology, Excelcare Hospitals, Guwahati, India
2 NL Medicare and Research Centre, Guwahati, India
3 Senior Consultant Endocrinologist, Guwahati, India
4 Department of Endocrinology, Gauhati Medical College, Guwahati, Assam, India
5 Department of Accident and Emergency, Excelcare Hospitals, Guwahati, India
6 Director of Medical Education, Assam, India
7 Department of Laboratory Medicine, Excelcare Hospitals, Guwahati, India
8 Dr. Shroff's Charity Eye Hospital, New Delhi, India

Correspondence Address:
Dr. Manash P Baruah
Excelcare Hospitals, Guwahati - 781 033, Assam
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/trp.trp_5_19

Rights and Permissions

Background: Thyroid disorders have emerged as a common disease in India. Hence, it is pertinent to search the real reasons behind the high prevalence of thyroid disease in India, post salt iodization phase. Objective: This study was executed to unravel the nature of thyroid disorders and there associations with thyroid autoimmunity in the unexplored North east Indian region. Methods: This community based Cross sectional (pilot) survey involved 8 wards of Guwahati city, implementing the “cluster sampling technique”. Abnormal thyroid parameters were classified as Hypothyroid: serum T4 < 4.6 μg/dL and Thyroid stimulating hormone (TSH) > 4.2) μIU/mL; Subclinical hypothyroidism (SCH): normal serum T4 (4.6-12 μg/dL) and TSH > 4.2 IU/mL, and Anti-TPO antibody positive: titre of ≥ 34 IU/ml. Results: Out of the 209 subjects enrolled, incidence of newly detected SCH, self reported hypothyroidism, and cumulative figure of the hypothyroidism cohort were higher amongst female population (27.84%, 14.43%, and 42.27% respectively). Significant association was found between female sex and hypothyroidism [Relative risk (RR) 1.73 (1.16-2.56), P < 0.01]. Significant association was found between family history of thyroid disease and SCH (RR 2.59), elucidating a direct influence of heredity on pre-disposition towards thyroid disorder. Conclusion: A considerable percentage (33.01%) of the adult population in Guwahati city has some form of thyroid disorder. There is lack of evidence pointing out auto immunity being the major driver for primary hypothyroidism; hence we are left to reflect upon whether dietary iodine deficiency or being geographically located near to the sub-Himalayan goitrogenic belt, or frequent consumption of cyanogenic food stuffs, is cumulatively involved in thyroid disorder development.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded456    
    Comments [Add]    
    Cited by others 2    

Recommend this journal