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Year : 2020  |  Volume : 17  |  Issue : 3  |  Page : 149-151

Antithyroid drug-induced pancytopenia followed by acute lymphoblastic leukemia: A rare case

1 Department of Medicine, SP Medical College, Bikaner, Rajasthan, India
2 Department of Pathology, SP Medical College, Bikaner, Rajasthan, India
3 Department of Medical Oncology, SP Medical College, Bikaner, Rajasthan, India

Correspondence Address:
Dr. Hardeva Ram Nehara
Department of Medicine, SP Medical College, Bikaner - 334 001, Rajasthan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/trp.trp_45_20

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Antithyroid drugs (ATDs) have been used for the management of hyperthyroidism and rarely may cause life-threatening side effects such as agranulocytosis and pancytopenia. Lymphocytes of patients who develop agranulocytosis while on ATD may undergo blast transformation when exposed in vitro to ATD. A 26-year-old man with Graves' disease was found to have pancytopenia after treatment with carbimazole for 2 months, which was improved with supportive treatment. The patient restarted carbimazole and presented 4 months later with a diagnosis of acute lymphoblastic leukemia (ALL). This case of ALL was likely attributed by re-exposure to carbimazole, though the association of ALL with autoimmune thyroid disease cannot be denied.

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