Thyroid Research and Practice

: 2006  |  Volume : 3  |  Issue : 3  |  Page : 71--75

Dehydroepiandrosterone supplementation in hypothyroidism

S Kalra1, B Kalra2, G Nanda3 
1 Endocrinologist, Bharti Hospital, Karnal, Haryana, India
2 Gynecologist, Bharti Hospital, Karnal, Haryana, India
3 Resident, Bharti Hospital, Karnal, Haryana, India

Correspondence Address:
S Kalra
Endocrinologist, Bharti Hospital, Karnal, Haryana

Dehydroepiandrosterone sulphate (DHEA-S) deficiency is a common but under diagnosed cause of asthenia. The aim of the study was to assess the frequency of DHEA-S deficiency in hypothyroidism, its clinical correlates, and the effect of DHEA supplementation in these patients. consecutive well-controlled hypothyroid patients, complaining «SQ»asthenia«SQ» for ii month were assessed for DHEA-S levels. Patients with low DHEA-S or with levels in the lower quartile of normal were supplemented with oral DHEA. Monthly follow-up was done to assess biochemical and clinical results, aiming for a DHEA-S level in the upper half of normal range. out of 72 patients had DHEA-S deficiency. The average dose of DHEA required to correct DHEA-S levels at 6 months was 18.75 ± 6.30mg/day. 82.60% patients reported marked improvement while 8.69% felt fair improvement in their symptoms with DHEA supplementation. There was no change in thyroxine dose requirement. A significant number of patients felt improvement in Libido (62.50%) and erectile function (25.0%). 8.71% dropped out due to various side effects. To conclude, DHEA-S deficiency is an easily treatable cause of asthenia in hypothyroidism.

How to cite this article:
Kalra S, Kalra B, Nanda G. Dehydroepiandrosterone supplementation in hypothyroidism.Thyroid Res Pract 2006;3:71-75

How to cite this URL:
Kalra S, Kalra B, Nanda G. Dehydroepiandrosterone supplementation in hypothyroidism. Thyroid Res Pract [serial online] 2006 [cited 2022 May 21 ];3:71-75
Available from:;year=2006;volume=3;issue=3;spage=71;epage=75;aulast=Kalra;type=0