Thyroid Research and Practice

: 2013  |  Volume : 10  |  Issue : 4  |  Page : 3--4

TSH and longevity

Subhankar Chowdhury, Partha P Chakraborty 
 Department of Endocrinology & Metabolism; IPGME&R/SSKM Hospital, Kolkata, India

Correspondence Address:
Subhankar Chowdhury
Professor & Head, Department of Endocrinology & Metabolism, Ronald Ross Building; 4th Floor, IPGME&R/SSKM Hospital, 244, A. J. C Bose Road, Kolkata - 20

The process of normal aging affects the hypothalamic-pituitary-thyroid axis in a number of ways, resetting of the set point being the most important of them. Contrary to the earlier belief, longevity has been reported to be associated with high serum TSH. Most recent studies have demonstrated an age dependent decline in serum free T3 levels, whereas FT4 levels remains relatively unchanged and TSH & rT3 levels increase with age. Two recent meta-analyses have shown increased risk of adverse cardiovascular outcomes in patients younger than 65 years of age, but not in those more than 65 year old. There is a good number of evidence documenting increased mortality in elderly individual with sub- clinical hyperthyroidism, which should be kept in mind while treating mildly elevated TSH in these patients. It is also important to remember that thyroid functions in the elderly closely mimics that found in sick euthyroid syndrome.

How to cite this article:
Chowdhury S, Chakraborty PP. TSH and longevity.Thyroid Res Pract 2013;10:3-4

How to cite this URL:
Chowdhury S, Chakraborty PP. TSH and longevity. Thyroid Res Pract [serial online] 2013 [cited 2022 May 17 ];10:3-4
Available from:;year=2013;volume=10;issue=4;spage=3;epage=4;aulast=Chowdhury;type=0