Thyroid Research and Practice

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 15  |  Issue : 1  |  Page : 23--28

Vitamin D levels in children with Hashimoto's thyroiditis: Before and after L-thyroxine therapy


Navendu Chaudhary1, Rakesh Kumar1, Naresh Sachdeva2, Devi Dayal1 
1 Department of Paediatrics, Advanced Paediatrics Centre, Chandigarh, India
2 Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Dr. Rakesh Kumar
Department of Paediatrics, Advanced Paediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012
India

Background: Vitamin D deficiency has been associated with Hashimoto's thyroiditis (HT). Hypothyroidism per se can cause poor absorption and metabolism of Vitamin D leading to Vitamin D deficiency. It is unknown that Vitamin D deficiency in HT is a cause or effect of HT. Objectives: To study Vitamin D level in children with newly diagnosed HT and to follow the changes in Vitamin D level after L-thyroxine therapy. Material and Methods: A prospective observational study was conducted on 35 children recently diagnosed with HT who had not received Vitamin D supplementation in the past 6 months. Serum 25 hydroxy Vitamin D levels along with serum calcium profile were estimated before starting L-thyroxine and on follow-up after 3 months. Results: The mean Vitamin D level at diagnosis of HT was significantly low as compared to controls (33.34 ± 16.93 nmol/L vs. 65.13 ± 30.57 nmol/L; P < 0.0001). Out of 22 Vitamin D-deficient patients who were treated, seven (31.8%) remained deficient at follow-up. Thirteen patients (sufficient/insufficient Vitamin D levels) who were not supplemented with Vitamin D had fall in Vitamin D levels in follow-up. Conclusions: Children with HT have low Vitamin D levels at diagnosis, and L-thyroxine therapy can further compromise Vitamin D status. Children with recent diagnosis of HT should be screened and treated or supplemented with Vitamin D.


How to cite this article:
Chaudhary N, Kumar R, Sachdeva N, Dayal D. Vitamin D levels in children with Hashimoto's thyroiditis: Before and after L-thyroxine therapy.Thyroid Res Pract 2018;15:23-28


How to cite this URL:
Chaudhary N, Kumar R, Sachdeva N, Dayal D. Vitamin D levels in children with Hashimoto's thyroiditis: Before and after L-thyroxine therapy. Thyroid Res Pract [serial online] 2018 [cited 2022 Aug 13 ];15:23-28
Available from: https://www.thetrp.net/article.asp?issn=0973-0354;year=2018;volume=15;issue=1;spage=23;epage=28;aulast=Chaudhary;type=0