Thyroid Research and Practice

CASE REPORT
Year
: 2019  |  Volume : 16  |  Issue : 1  |  Page : 36--38

An uncommon presentation of a common disorder: Van Wyk–Grumbach syndrome


Beatrice Anne1, Vidyasagar Simhadri2, Vamsi Krishna Yerramneni3, D Neusha1 
1 Department of Endocrinology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India
2 Department of General Medicine, Alluri Sitaramaraju Academy of Medical Sciences, Eluru, Andhra Pradesh, India
3 Department of Neurosurgery, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India

Correspondence Address:
Dr. Beatrice Anne
Department of Endocrinology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad - 500 082, Telangana
India

Van Wyk–Grumbach syndrome (VWGS) is characterized by juvenile hypothyroidism, delayed bone age, and isosexual precocious puberty. We report the case of a 7-year-old girl who presented with premature menarche, short stature, and isosexual precocity. She had delayed bone age and multicystic ovaries. High circulating levels of thyroid-stimulating hormone (TSH) with prepubertal luteinizing hormone confirmed the diagnosis of VWGS. High circulating levels of TSH acting directly on follicle-stimulating hormone receptors could be the mediators of precocity. VWGS syndrome is quite rare and needs to be suspected for prompt treatment and resolution and avoidance of unnecessary surgery.


How to cite this article:
Anne B, Simhadri V, Yerramneni VK, Neusha D. An uncommon presentation of a common disorder: Van Wyk–Grumbach syndrome.Thyroid Res Pract 2019;16:36-38


How to cite this URL:
Anne B, Simhadri V, Yerramneni VK, Neusha D. An uncommon presentation of a common disorder: Van Wyk–Grumbach syndrome. Thyroid Res Pract [serial online] 2019 [cited 2022 Sep 30 ];16:36-38
Available from: https://www.thetrp.net/article.asp?issn=0973-0354;year=2019;volume=16;issue=1;spage=36;epage=38;aulast=Anne;type=0