Thyroid Research and Practice

CASE REPORT
Year
: 2019  |  Volume : 16  |  Issue : 3  |  Page : 140--143

Diagnostic issue and caveats of immunoreactivity for Ki67 in hyalinizing trabecular neoplasm with a review of literature


Veer Karuna1, Priya Gupta1, Mamta Gupta2, Kriti Grover1 
1 Department of Pathology, LLRM Medical College, Meerut, Uttar Pradesh, India
2 Department of Pathology, Subharti Medical College, Meerut, Uttar Pradesh, India

Correspondence Address:
Dr. Veer Karuna
Department of Pathology, LLRM Medical College, Meerut, Uttar Pradesh
India

Few benign and malignant tumors of thyroid lesion share many histological features, including papillary and trabecular pattern, hyalinized stroma, calcification, nuclear grooving, and nuclear inclusion. The lesions those have these common features are hyalinizing trabecular tumor, papillary thyroid carcinoma, medullary carcinoma, paraganglioma, trabecular follicular adenoma (TFA), and poorly differentiated tumor (PDT). These tumors are derived from thyroid follicular cell except PDT and paraganglioma. Hyalinized trabecular tumor and TFA are rare tumors. Due to these common features, they create a diagnostic pitfall for a false-positive or false-negative diagnosis. Therefore, histopathological and immunohistochemical studies are needed to make a definite diagnosis. The present case describes a relatively rare thyroid tumor – hyalinizing trabecular tumor – with its varied morphological features creating diagnostic difficulties and role of immunohistochemistry in formulating definitive diagnosis.


How to cite this article:
Karuna V, Gupta P, Gupta M, Grover K. Diagnostic issue and caveats of immunoreactivity for Ki67 in hyalinizing trabecular neoplasm with a review of literature.Thyroid Res Pract 2019;16:140-143


How to cite this URL:
Karuna V, Gupta P, Gupta M, Grover K. Diagnostic issue and caveats of immunoreactivity for Ki67 in hyalinizing trabecular neoplasm with a review of literature. Thyroid Res Pract [serial online] 2019 [cited 2022 Aug 13 ];16:140-143
Available from: https://www.thetrp.net/article.asp?issn=0973-0354;year=2019;volume=16;issue=3;spage=140;epage=143;aulast=Karuna;type=0