Thyroid Research and Practice

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 18  |  Issue : 2  |  Page : 61--66

Fasting versus postprandial state: Impact on thyroid function testing


Dheeman Futela, K Maheswari, Tejasvini Khanna 
 Department of Biochemistry, Maulana Azad Medical College, New Delhi, India

Correspondence Address:
Dr. K Maheswari
Department of Biochemistry, Maulana Azad Medical College, New Delhi
India

Context: Thyroid dysfunctions are common health problems worldwide. Thyroid function tests (TFTs) are the mainstay of diagnosis. A common question by labs and clinicians is whether food intake makes a clinically significant difference for TFTs. Aims: We aimed to assess the effect of fasting and postprandial state on thyroid-stimulating hormone (TSH), free T3, and free T4. Settings and Design: A cross-sectional study was conducted. Sixty patients were prospectively selected. Subjects and Methods: Patients were divided into two groups: Group A (known case of thyroid disorder and on medication) and Group B (no prior history of thyroid dysfunction). Two blood samples were collected from each patient, before and after breakfast, with a gap of 2 h. Serum samples were analyzed for TSH, free T3, and free T4. Results: Mean (± standard deviation) TSH values (mIU/L) in fasting state were 2.38 ± 1.88 and in postprandial state were 2.08 ± 1.65. A statistically significant postprandial decline was observed in TSH values (mean difference: -0.30 mIU/L) and free T3 (mean difference: –0.21 pmol/L), in both groups. Conclusions: TFT results were altered in a statistically significant manner after food intake. Multiple studies have reported a similar postprandial decline in serum TSH. This may impact the diagnosis and management of thyroid patients, especially where minor changes in TSH levels are clinically relevant.


How to cite this article:
Futela D, Maheswari K, Khanna T. Fasting versus postprandial state: Impact on thyroid function testing.Thyroid Res Pract 2021;18:61-66


How to cite this URL:
Futela D, Maheswari K, Khanna T. Fasting versus postprandial state: Impact on thyroid function testing. Thyroid Res Pract [serial online] 2021 [cited 2022 Dec 2 ];18:61-66
Available from: https://www.thetrp.net/article.asp?issn=0973-0354;year=2021;volume=18;issue=2;spage=61;epage=66;aulast=Futela;type=0