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   2006| September-December  | Volume 3 | Issue 3  
    Online since December 7, 2011

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Dehydroepiandrosterone supplementation in hypothyroidism
S Kalra, B Kalra, G Nanda
September-December 2006, 3(3):71-75
Dehydroepiandrosterone sulphate (DHEA-S) deficiency is a common but under diagnosed cause of asthenia. The aim of the study was to assess the frequency of DHEA-S deficiency in hypothyroidism, its clinical correlates, and the effect of DHEA supplementation in these patients. consecutive well-controlled hypothyroid patients, complaining 'asthenia' for ii month were assessed for DHEA-S levels. Patients with low DHEA-S or with levels in the lower quartile of normal were supplemented with oral DHEA. Monthly follow-up was done to assess biochemical and clinical results, aiming for a DHEA-S level in the upper half of normal range. out of 72 patients had DHEA-S deficiency. The average dose of DHEA required to correct DHEA-S levels at 6 months was 18.75 ± 6.30mg/day. 82.60% patients reported marked improvement while 8.69% felt fair improvement in their symptoms with DHEA supplementation. There was no change in thyroxine dose requirement. A significant number of patients felt improvement in Libido (62.50%) and erectile function (25.0%). 8.71% dropped out due to various side effects. To conclude, DHEA-S deficiency is an easily treatable cause of asthenia in hypothyroidism.
[ABSTRACT]   Full text not available  [PDF]
  1,126 266 -
Screening for neonatal hypothyroidism : A review
AM Samuel
September-December 2006, 3(3):76-88
This is an in-depth article focusing on the controversies that surround the issue of neonatal screening for hypothyroidism
[ABSTRACT]   Full text not available  [PDF]
  886 192 -
Cretinism : A 25 - year follow up
Ratan KR Kotokey
September-December 2006, 3(3):89-91
Full text not available  [PDF]
  610 182 -
What is the optimal thyroid hormone replacement and how far are we from individualising thyroid hormone therapy?
P Saravanan
September-December 2006, 3(3):67-70
Full text not available  [PDF]
  553 213 -
Reply to letter by Dr. Kumaresan
A Naveen, TK Sabeer, A Bhattacharyya
September-December 2006, 3(3):94-94
Full text not available  [PDF]
  509 191 -
Thyroid Watch
MG Pillai
September-December 2006, 3(3):92-92
Full text not available  [PDF]
  464 165 -
Letter to Editor
K Kumaresan
September-December 2006, 3(3):93-93
Full text not available  [PDF]
  431 181 -